What is CRISPR test?

India’s first CRISPR test for COVID-19 has been launched by the TATA group. It has been named ‘Feluda’, the TATA CRISPER (Clustered Regulatory Interspaced Short Palindromic Repeats) COVID-19 test.  The test recently received regulatory approvals for the commercial roll out from the Drug Controller General of India (DCGI).

Key Facts

  • The Tata CRISPR test is the world’s first diagnostic test that will deploy a specially adapted Cas9 protein in order to detect the virus that is causing the COVID-19.
  • For the detection of  the SARS-CoV-2 virus, test uses indigenously developed CRISPR technology

CRISPR technology?

  • CRISPR is Clustered Regularly Interspaced Short Palindromic Repeats.
  • CRISPR are the Family of DNA sequences that are found in the genomes of prokaryotic organisms that includes bacteria and archaea.
  • The protein Cas9 which is also called as “CRISPR-associated” is an enzyme that acts like a pair of molecular scissors which is capable of cutting the strands of DNA.
  • The technology was first adapted from the natural defence mechanisms of bacteria and archaea .
  • This technology was first unveiled in 2012.
  • These bacteria and archaea uses the CRISPR-derived RNA and  Cas proteins like Cas9 in order to foil attacks by viruses and other foreign bodies. They do so by eating up and destroying the DNA of a foreign bodies.
  • CRISPR technology is a powerful tool for editing genomes.
  • The technology allows researchers to easily alter DNA sequences and modify gene function.

Application of the CSISPR technology

Potential applications of the technology include- correcting genetic defects, Improving crops and  treating and preventing the spread of diseases.

However, before the CSISPR method, there were several ways to edit the genomes of some plants and animals but they were highly charged. The CRISPR technology is cheap and easy.

Archaea

Archaea are a domain of single-celled organisms. These microorganisms does not have cell nuclei so they are prokaryotes. Archaeal cells can separate themselves from Bacteria and Eukaryota. This is the unique property of Archaea.

Bacteria

Bacteria is a biological cell. They contains a large domain of prokaryotic microorganisms. Typically, they are a few micrometers in length.  They can be spherical, rods shaped and spirals. Bacteria were among few forms that appear on Earth first. The study of bacteria is known as bacteriology.