The OTOF gene is crucial for hearing. It encodes a protein essential for the function of inner ear hair cells. Mutations in this gene can lead to auditory neuropathy. This condition affects sound transmission. Understanding the OTOF gene aids in genetic counselling. It also contributes to advancements in audiology. Research continues to explore its implications for hearing loss treatments.
On 23 April 2026, the United States Food and Drug Administration approved Otarmeni (lunsotogene parvec-cwha), the first dual adeno-associated virus vector-based gene therapy for inherited hearing loss. The...
