The ACE2 or angiotensin converting enzyme 2 is a human enzyme which is known for enabling the SARS CoV 2 viral particles to infect cells. The ACE2 gene is linked to the X chromosomes of humans- hence females have twice as many active genetic instructions as males for production of ACE2. Recent research shows that ACE2 has a significant role in protection from diseases affecting the lungs, kidneys and heart. It also explains why female patients of COVID-19 are less susceptible to severe complications than male patients.