LZTFL 1 stands for Leucine zipper transcription factors like 1, are ubiquitously expressed proteins located in the cytoplasm and encoded by the human LZTFL1 gene. This protein regulates the transport of protein to the ciliary membrane by interacting with the Bardet-Biedl Syndrome protein complex.


Genes regulate protein trading. Protein transport means the movement of proteins within the cell. LZTFL1 is a gene that suppresses tumour. Mutations in LZTFL1 cause Bardet-Biedl syndrome. This gene is located on human chromosome 3. The Neanderthals inherited the LZTFL1 from Homo sapiens.

Connection with COVID-19

In the month of November, 2021, researchers discovered that the LZTFL1 gene doubled the risk related to respiratory failure in COVID 19. This gene can be found in more than 60 percent of the South Asian population. On the other hand, 2% of Caribbean’s and Africans and only 15% of Europeans carry this gene. This is why Asians are more vulnerable to the COVID-19 virus. Researchers have found that this gene prevents cells lining the lungs and respiratory tract from responding to the coronavirus. Therefore, the respiratory failure risk increases. Genes only affect how the lungs respond, not the immune system.