DNA vaccines effective in Hamsters: COVID-19

Using DNA of the Coronavirus spike protein, researchers from Taiwan have developed a vaccine and tested its effectiveness on a group of hamsters and mice. This newly developed technique is different from the mRNA vaccines.

About the research

  • Usually the DNA vaccines are hard to deliver into cells. But, the researchers from the National Health Research Institutes, Taiwan, made use of electroporation (a technique in which electrical field is used on cells to increase permeability) while delivering the DNA vaccination.
  • According to the results of the research, the hamsters and mice which were immunised with the new DNA vaccine developed antibodies against the SARS-CoV-2 spike protein or the COVID-19 virus.
  • Eight weeks after immunisation the antibodies peaked but levels were relatively high even at week 20 after immunisation.

DNA Vaccine

High levels of long-lasting neutralising antibody against the COVID-19 virus can be induced by the DNA Vaccines.  DNA Vaccines can be produced very quickly at cost lower than the others. Several clinical trials worldwide have indicated the efficiency of DNA vaccines in treating various infections like Zika, Ebola, influenza viruses and HIV-1.

mRNA Vaccines

Most of the available Covid-19 vaccines that are being used to vaccinate people are based on mRNA strands. The mRNA vaccines teach the human immune system to recognize the COVID-19 virus and act against it.

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