Institute of Nano-Science and Technology (INST), Mohali, has developed an iron-based metal-organic framework (Fe-MOF) that can detect nicotine and cotinine through fluorometric sensing. The material remains weakly fluorescent under normal conditions, but emits a bright signal when it comes into contact with these tobacco-related compounds. The development may support quick detection of tobacco exposure in healthcare and research settings.
What the material is
The sensor is an Fe-MOF, a nano-scale porous structure made from iron and organic molecules. Its tiny pores allow it to interact with target molecules. Such materials are valued in sensing applications because they can be designed for selectivity, sensitivity and reuse.
How detection works
- The material shows low fluorescence in its normal state.
- When nicotine or cotinine is present, the fluorescence increases sharply.
- This light-up response makes detection fast and easy.
- It can identify even small quantities with high accuracy.
Health and research relevance
The sensor is currently at the in-vitro stage, but it has been found biocompatible and safe for biological systems. It works in water and under different conditions, and is not easily disturbed by common substances present in the body. This improves reliability in real-world samples. The material is also reusable, which may reduce testing costs.
Future applications
The technology may be used for real-time monitoring at the cellular level and, later, for blood-based testing of nicotine and cotinine levels. It could help in:
- Early detection of tobacco exposure.
- Monitoring second-hand smoke exposure.
- Supporting smoking cessation programmes.
- Developing simple diagnostic kits.